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The early replicated part was defined as being replicated before initiation of the small chromosome, assuming an equal bi-directional replication speed for both chromosomes and a synchronous termination.
Considering the tight connection between DNA replication and the other cell cycle events, a link between the replication speed and the accessibility of the origins is likely.
The fitness of an organism is essentially its replication speed.
Nevertheless, our results confirm a fast replication speed for vibrios.
This suggests that the virus passaged in the KG1 cells had an enhanced replication speed.
I personally doubt that selection for replication speed would tend to favour wild-type mitochondria.
Similar(24)
Phagocytosis, once it has evolved, breaks this loop, as success no longer depends on replication speed--a phagocyte can simply eat the opposition, and the faster they replicate the more it has to eat.
Together with potentially ubiquitously present differences in organelle replication speeds, this can lead to a hitchhiking of cytoplasmic incompatibilities.
Hence, it appears unlikely that solely differences in oDNA replication speeds provide sufficient driving force for the evolution of uniparental inheritance.
The replication fork speed was found to be gradually reduced proportionately to moderate reductions in nucleotide availability.
The relative frequency of gene copies around the chromosome was exactly the same in SMG386 grown with 10 µM IPTG as in the control, indicating that the decrease in replication fork speed is on average distributed evenly throughout the chromosome (data not shown).
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