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The information encoded in the nucleotide sequence of DNA is, as a rule, faithfully reproduced during replication, so that each replication results in two DNA molecules that are identical to each other and to the parent molecule.
Occasionally "mistakes," or mutations, occur in the DNA molecule during replication, so that daughter cells differ from the parent cells in the sequence or in the amount of DNA.
First, a hereditary molecule must be capable of replication so that the information can be passed on to the next generation; therefore, Watson and Crick hypothesized that, if the two halves of the double helix could separate, they could act as templates for the synthesis of two identical double helices.
The compensatory mechanisms are sufficient to allow replication so that the specific mutants exhibit at most marginal attenuation in vivo.
In addition, HCT-8 cells may lack some element required for virus replication so that only limited amounts of virus particles are produced.
This tissue-specific profile is maintained during cell replication so that the daughter cells will retain the cell type identity of the parental cell (cellular memory), even when cell activity must change in response to intrinsic and extrinsic signals.
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Its new "Preclinical Reproducibility and Robustness channel," launched today, will allow both companies and academic scientists to share their replications so that others will be less likely to waste time following up on flawed findings, says Sasha Kamb, senior vice president for research at Amgen in Thousand Oaks, California.
The source vehicle S meets R1 and R2 sequentially; they satisfy the replication condition so that S gives duplications of the data to both vehicles.
Units of replication optimized for replication rate so that only one strand can be catalytic achieve slightly higher replication rates than those in the full model.
"They're about the same size as laptop computers," he said, "and a laptop has a keyboard, so that's a replication of the alphabet.
Normally, protein kinase UL97 functions to drive cells into the S phase so that viral DNA replication can take place.
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