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Viral replication significantly alters the gene expression landscape of infected cells.
Incorporation of HIV protease inhibitors in the HAART causes profound and sustained suppression of viral replication, significantly reduces the morbidity and mortality, and prolongs the lifespan of patients with HIV infection [1], [2].
Viral replication significantly decreased in the AGO1a-Res plants.
Infection of HBV transgenic mice with adenoviruses [ 14, 63] or AAVs [ 43, 64] carrying Pol II- or Pol III-driven anti-HBV shRNA cassettes inhibited viral replication significantly.
In this study, we demonstrated that the application of curcumin at the early stage of EV71 replication significantly suppressed viral RNA synthesis, viral protein expression and the overall viral progeny production.
The compartment contains large amounts of replication enzymes and the time lag generated by frequent dissociation/reassociation of polymerases at the replication fork might be short enough to not impede replication significantly.
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(ii) In most of the other microbial genomes with asymmetric mutational bias, the genes, especially the highly expressed ones, are present in the leading strands of replication in significantly higher numbers, the phenomenon referred to as replicational-transcriptional selection [ 2, 3, 34, 35].
Ad replication is significantly stimulated by three cellular proteins (NFI/CTF, NFII, and NFIII/Oct-1).
Early and late viral gene expression as well as DNA replication were significantly reduced in a functional pRB-pathway-dependent manner, resulting in a restricted replication profile similar to that of nonreplicating adenoviruses in normal cells both in vitro and in vivo.
HIV replication was significantly inhibited in all cell lines expressing NS5A amino acids 152 165.
As expected the magnitude of HIV replication was significantly lower in the control Jurkat cells compared to the control MT-2 cells (Fig. 8B).
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