HIV gp120 induced maximal HIV replication, yet in this context, HIV replication reflected virus produced from cells infected with HIV in vivo.
Viral replication, reflected by Gag p24 protein levels in culture supernatants, was strongly decreased in MDDC cocultured with CD85j+ NK cells compared to MDDC without NK cells (Fig. 2b).
> -wrap-foot> Our data shows that highly enriched GO groups in S1 cells correspond to metabolic processes or other housekeeping functions, such as cellular respiration and DNA replication, reflecting the normal nature of these cells.
"Our takeaway is that the replication rate is rather good," says Camerer, noting that the study topics from the successful replications reflect "most of the things we study in experimental economics [that] are replicated over and over: Do prices move toward where supply meets demand?
At least a proportion of these failed replications reflect heterogeneity in LD between causal variants and the tag SNPs used in GWAS panels so selection of alternative tags specific to the population used may improve reproducibility.
RNA viral genomes can originate from long-living infected cells producing viral particles in the absence of replication, or reflect a residual replication.
In bacterial chromosomes, the position of a gene relative to the single origin of replication generally reflects its replication timing, how often it is expressed, and consequently, its rate of evolution.
In general, a possible disadvantage for the use of the Kenyan samples as a replication study group is their different ethnic background: a lack of replication may reflect true ethnic heterogeneity in pneumococcal disease susceptibility.
In the in vitro models, using comparable infectious doses and by quantitating host responses at defined time points in a synchronous infection, it was possible to confirm that the difference in host responses between H5N1 and seasonal influenza are not merely reflections of the higher levels of virus replication, but reflect intrinsic differences of the virus.
Instead, the lack of replication may reflect the different traits examined (corneal versus refractive astigmatism).
