Here, we provide a complete analysis of the nucleosomal landscape and replication program of the human parasite Leishmania major, building on a better evolutionary understanding of replication organization in Eukarya.
The coherent view of replication organization and replisome action presented here is very different from that which has emerged from many other studies that have been interpreted within the framework of the replication factory model (Dingman, 1974).
The lamins play important roles in DNA replication, chromatin organization, regulation of gene expression, spatial organization of the nuclear pore and the correct anchorage of the nuclear envelope proteins, cell development, differentiation and apoptosis [5].
The nuclear lamina is a thin filamentous meshwork that provides mechanical support to the nucleus and regulates essential cellular processes such as DNA replication, chromatin organization, cell division, and differentiation.
Here we have investigated the effect of changes in ribonucleotide reductase (RNR) activity on chromosome replication and organization of replication forks in Escherichia coli.
It was found that cells with impaired function of thymidylate synthase (ThyA) seemed to exhibit a changed pattern of replication fork organization [24].
Nuclear lamins are intermediate filament proteins and have roles in various nuclear processes, including DNA replication, chromatin organization, and gene transcription [1] [4].
Nuclear lamin filaments and associated proteins form a nucleoskeletal ("lamina") network required for transcription, replication, chromatin organization and epigenetic regulation in metazoans.
In the case of proliferation these pathways include well-known processes associated with cell cycle progression and cell division: the G1/S transition, DNA replication, telomere organization, chromosome segregation, DNA packaging, the G2/M transition and cell division.
The multifunctional human transcriptional co-activator SUB1 is a highly abundant nuclear protein that plays a key role in various cellular processes such as transcription, replication, chromatin organization, cellular transformation, and DNA damage repair [10]– [10].
Consistent with increased cell proliferation in seeds with paternal excess and inhibited proliferation in maternalized seeds, many genes involved in DNA replication, chromatin organization, RNA translation, or protein synthesis were overexpressed in large seeds and/or down in small seeds.
