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As Schellenberg et al. say (2011), there are 'real-life' challenges in health systems (e.g. low coverage, late administration) that can act as significant constrain to the replication of trial results.
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This edition of the Cochrane Review adds the DEVTA trial from India, and draws on an independent analytical replication of a trial from Kenya.
We evaluated the precision and the accuracy of parameter estimates obtained on 500 replication of this trial using the stochastic approximation expectation-approximation algorithm which appropriately handles BLD data.
The detailed descriptions about implementation provided by the narratives shared in semistructured interviews will inform future replication of the trial and its wider implication by understanding the scope and limits of generalisability.
The first (i) being independent replication of clinical trial data analysis to verify the regulatory authority's positions and challenge them where appropriate, and the second (ii) related to secondary analyses enabling the wider scientific community to make use of detailed and high-quality clinical trial data to develop new knowledge in the interest of public health.
The authors attempted a replication of a trial previously conducted in the USA [ 21] (which was excluded from this review since their primary outcome was not social network size) and adapted their study to include a stipend for one arm and an explicit measure of social network size.
Another important question in this context is whether sole replication of clinical trials' data analyses makes it really possible to (fully) understand the regulator's decision.
Differences in costs between the intervention group and the control group will presented based on the trial data, and 95% confidence intervals will computed based on bootstrap re-sampling with 5000 replications of the trial data.
Because of multiple replications of clinical trial information and press announcement recycling, unfiltered Google searching with drug code names used in clinical trials has become effectively useless.
Three replications of each trial were performed.
Replications of this trial need to be performed to establish consistency of research findings.
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CEO of Professional Science Editing for Scientists @ prosciediting.com