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This process is repeated V times without replication of the validation dataset.
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Within each replication of the cross-validation, 80% of RILs (3484) of each family were randomly sampled without replacement from the 4354 common RILs to use as a training set.
We subsequently tested for replication using the validation VASST cohort of European ancestry, which was successfully genotyped for IL17A rs1974226.
To assess the reproducibility and robustness of promising preclinical interventions, the workshop participants recommended independent replication of the original findings and validation in more than one RTT mouse model or strain prior to launching later-stage translational or clinical projects.
We emphasize the role of (systematic and extended) replications in the course of the validation process.
Many challenges still exist after this first wave of GWA studies, and one of them is the validation and replication of the positive hits from the GWA screening.
Validation and/or replication of the results provides valuable support to research findings.
Previously, increased expression of MSL1 was correlated with earlier time to relapse [2]; additional validation of the prognostic model and replication of the etiologic association are warranted.
However, replication of the present findings in an independent sample is warranted for the ultimate validation of the proposed instrument.
To make these scales more psychometrically meaningful for breast cancer population, they would benefit from replication of validation studies in this context.
If the same subjects are used in both steps, the predictive validation is circular (non-independent) and there is no replication of the structure-function relationships.
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