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A replication of the effect using a completely counterbalanced design is described in Experiment 1b.
Replication of the effect of SIK3 rs681524 genotypes on hearing function would be useful.
The effect of dose in our study might, however, be a replication of the effect of cumulative use because a high dose was more likely to be prescribed for patients who had been on statins for substantial period of time.
Although our data did not allow for replication of the effect on insulin secretion, in meta-analysis we report a borderline association for fasting glucose levels (p ≤ 0.016), which considering the size of our study suggests that this effect is not as strong as that on insulin secretion reported by Rosengren et al. [ 4].
In the Framingham Heart Study (14), the HHIP region was associated with FEV1/FVC at genome-wide significance with replication of the effect on FEV1/FVC demonstrated in an independent sample drawn from the Family Heart Study, and this same region nearly reached genome-wide significance with COPD susceptibility in the Pillai paper (12).
Importantly, an effect of amygdala pathology on the ERPs was considered only if the MTLE-amygdala patients significantly (uncorrected P < 0.01 = FWE P < 0.08) differed from both the control groups (healthy and MTLE-control), thus allowing a replication of the effect, while also controlling for epileptic condition.
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The effect of AMI is stronger in the replication phase, but the vast majority of the genes showing highly significant differential expression in either direction in the replication phase (red or blue spots highlighted in Figure 1D) showed the same direction of effect in the discovery phase, indicating replication of the AMI effect.
We imagine that a database of kernels will emerge, much like the human genome project (i.e., http://genomics.energy.gov/) wherein the breadth, depth, magnitude, and replications of the effects of any given kernel might be reported by the international research community in order to build an open-source molecular technology of behavioral influence.
The replication of these effects across native and non-native Chinese speakers demonstrates that the results were not driven by differences in ethnicity (see Table II).
To further test the specificity of MIR2911-mediated inhibitiof of viral replication, the effect of MIR2911 or HS decoction on H1N1 replication, after mutating the MIR2911-binding sines in the PB2 and NS1 genes without changing the amino acid sequences, was assessed (Supplementary information, Figure S6).
Altogether, these in vitro binding experiments suggest that QC can strongly interfere with binding of p33 to the TBSV RNA, thus inhibiting the recruitment of repRNA into replication, whereas the effect of CPZ on the interaction might only be effective at lower p33 concentrations (e.g., in the beginning of infection).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com