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If repair of damaged DNA is slow, error-prone, or not accomplished at all and cell replication occurs, the damage is amplified and becomes a permanent (fixed) mutation.
The central nervous system (CNS) is a classic model of sanctuary where viral replication occurs despite a complete viral suppression in peripheral blood.
Infection occurs via the fecal oral route, meaning that one ingests the virus and viral replication occurs in the alimentary tract.
Feline calicivirus replication occurs within the replication complexes formed in the cytoplasm [43].
Efficient replication occurs later, attributed to efficient but late-firing origins.
It is intriguing to find that efficient replication occurs late in S-phase.
To further prove that VSV replication occurs independently of cell cycle, we used RNA interference (Fig. 7A and B).
Following the expression of these genes, genome replication occurs as a function of the availability of dNTPs, N (Fig. 1).
Indeed, prion replication occurs in lymphoid tissues long before neuroinvasion and subsequent detection in the central nervous system (CNS) [6].
Note, element replication occurs with a small probability to ensure that local element-element mechanical equilibrium is not strongly perturbed.
We demonstrate that SIV replication occurs in the brain as early as 4 days p.i., predominantly in perivascular macrophages.
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