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Such genomic expansion was likely facilitated by the evolution of DNA replication machinery capable of replicating larger genomes [ 63].
The DNA replication machinery is unable to replicate telomeres completely.
The virus cannot replicate inside the caterpillar, because all of its replication machinery is inside the wasp.
Replication errors are minimized when the DNA replication machinery "proofreads" its own synthesis, but sometimes mismatched base pairs escape proofreading.
Another important question is how DNA replication machinery guides the inheritance of various chromatin states.
Depriving viruses of crucial replication machinery, TIPs would reduce viral loads.
Interference can be the product of immunodominance, direct competition for cellular or viral replication machinery, or immune-mediated apparent competition.
Viruses are known for hijacking a cell's DNA replication machinery for their own reproduction.
Many proteins involved in the replication machinery have been targeting signals that direct their association with the active sites.
Recent studies in fission yeast and other organisms provide significant insight into the role of DNA replication machinery in epigenetic inheritance.
This method takes advantage of the cell DNA replication machinery that remains active after snap-freezing.
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