These CNV PDGs are prone to replicate later than non-CNV PDGs, suggesting a link between CNVs, gene duplication and late replication in human cells.
A more perfect one-time measurement is almost certainly possible, but it would prevent this work from being subject to replication or later repetition and as such be less of a contribution to the science of cybersecurity.
Efficient replication occurs later, attributed to efficient but late-firing origins.
Interestingly we find that mice lacking STAT3 throughout the T-cell compartment also have similar viral load to control animals at early time points postinfection, but fail to control viral replication at later stages (Fig. 4A E).
This preference for certain codons within amino acid runs, suggests bias in DNA polymerase δ slippage or, alternatively, identical codon-repetitions produced during genome replication were later polished at the 3rd codon position by positive pressure arising from the translation process.
In contrast, an early replicating domain shifted to a later replication timing following neocentromere formation within it.
Histones, which are only required after replication is complete, peaked later, at around the end of S-phase (Fig. 5A, orange circles).
The result is the formation of an RNP, of which PTB is a component, which promotes replication at the later stages of the virus life cycle.
This result supports speculations from Sharp et al. [28] who suggested that, if infections with two well-adapted heterosubtypic viruses occur at different times, the first infectant may prevent the replication of a later infectant.
Therefore, these observations hold on in the analyses with the data of the first original study and the later replication study separately, making the observed association between plasma HO-1 concentrations and New-T2DM more convincing.
