Genetic knockout of ATG16L or ATG7 reverted the membrane encapsulation and restored parasite replication, indicating that core autophagy proteins involved in LC3 conjugation are important in the control of parasite growth.
The cps genes were induced by a subset of β-lactams but not by agents inhibiting protein synthesis or DNA replication, indicating that cps expression was specific and not due to stresses accompanying cell death or by a general inhibition of peptidoglycan synthesis.
Treatment of BJx109-infected mice with mAb RB6-8C5 was, however, associated with significant weight loss and enhanced virus replication indicating that other Gr-1+ cells, not neutrophils, limit disease severity during mild influenza infections.
The conditional depletion of HNF4α in the liver results in the loss of HBV transcription and replication indicating that this nuclear receptor is a major determinant of viral biosynthesis in vivo.
In addition, a recent study has shown that S. pombe yeast Cdc7 is limiting for initiation of DNA replication, indicating that other preRC (or pre-IC) subunits may be limiting in mammalian cells beyond Cdc45 [65].
Our results show dramatic cell-type dependent differences in the antiviral activities of RBV, ranging from virtually no effect to very effective inhibition of viral replication, indicating that some cell types are naturally resistant to RBV treatment even without prior exposure to this drug.
