Exact(5)
Inconsistent findings in factor structure and replication difficulties have limited the scope of development of the measure as a multi-dimensional tool.
may explain replication difficulties of effects of bilingual cognitive advantages (e.g., [ 18]; for a recent review, see [ 5]).
Furthermore, brc1Δ cells have increased Rad52 foci, which indicate DNA replication difficulties even in the absence of exogenous genotoxins (Bass et al. 2012; Williams et al. 2010).
Similarly, the full activation of both FANCD2 and PCNA, in addition to the resolution of DNA replication difficulties, could also participate in cell recovery from cell cycle checkpoints.
In a large number of Nde1−/− progenitors, CldU signals in IdU+CldU+ cells were predominantly detected along the nuclear periphery, the rim of nucleoli, and on particles of satellite repeats which are characteristic for heterochromatic domains, indicating replication difficulties in these domains during mid to late S phase.
Similar(55)
By discussing the difficulties of replication, we do not intend to depreciate the GWA approach and subsequent replication efforts.
Soto acknowledges there were difficulties with replication at first but says these have largely been overcome.
The reasons may be found in a complex set of unrelated problems of which difficulties in replication of low-dose stimulatory responses resulting from poor study designs, greater societal interest in high-dose effects, linking of the concept of hormesis to the practice of homeopathy, and perhaps most crucially a complete lack of strong leadership to advocate its acceptance in the right circles.
Despite the difficulties of replication under a complex model of disease, it is still important to have a strategy for analysis and interpretation of results.
However, the literature has also raised some criticism and important growing pains of the field are difficulties with replication and contradictory findings, which complicates creating a consistent picture (e.g., Dick et al. 2015; Duncan and Keller 2011; Jaffee et al. 2013; Rutter 2012).
The power of an experiment can be increased by replication of treatment conditions (difficulty IVD) and also by reducing influence of the unrelated variables (difficulty IVE).
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