Exact(3)
Apart from these DNA replication derived phenomena others arising from DNA transcription, mRNA stability and translation [5] [7] are also likely to fine tune ORFeomes' primary structure, but their significance is not yet fully understood.
PsA inhibited the subgenomic viral replication derived from genotype 1b and genotype 2a, with EC50 6.1 and 6.3 μM, respectively [ 69].
It is nevertheless surprising to note that the minimalist model of replication derived using an independent approach based on comparative genomics, resembles the initial model of dual displacement loop mode of replication, suggesting that it prevails at least during advanced developmental stages.
Similar(57)
The functional role of chromatin-bound MCMs in DNA replication is derived primarily from embryonic and yeast studies, where MCMs that are not functioning in DNA replication (with lower chromatin affinity) are blocked from entering, or exported out of, the nucleus [4], [41], [42], [43], [44].
The accuracy of DNA replication is derived from the balance between three important components: base selectivity by the replicative DNA polymerases (pols), exonucleolytic proofreading, and post-replicative mismatch repair.
The replication samples derived from two population-based Dutch cohorts and one Australian Twin study totaling 2,957 migraineurs and 5,774 non-migraineurs.
Our knowledge of MCM proteins and DNA replication is derived from research principally based on yeast and vertebrate animals.
Importantly, it has been shown that the highest inhibition on viral replication is derived from genotypes 1b and 2a with EC50 values of 1.5 and 24.9 μg/mL, respectively [ 68].
We found that the copy number of mtDNA in R2 and R3 samples of RH1 dsRNA-treated cells became significantly lower than that in D3 samples, yet the mtDNA replication intermediates derived from the strand-coupled DNA synthesis were relatively easily detected in the R2 sample without S1 nuclease treatment.
It is important to stress that the notion of early and late replication origin has intrinsic statistical nature because firing times come from an averaged replication profile deriving from a population-based microarray.
Furthermore, our network analysis has indicated that the proteins involved in reducing HIV replication may derive from multiple intersecting signaling pathways, although there is likely to be some level of redundancy in these regulatory and signaling cascades.
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