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Six days later, cells were further super-infected with replication defective Ad5-PGK-GFP.
A replication defective influenza A vaccine virus (delNS1 virus) was developed.
Currently, replication defective adenovirus-based Ebola vaccine is being studied in a phase I clinical trial.
We included the replication defective mWF10 as a Gln226-containing virus for comparison.
The replication defective Ad5 (Ad-GL) was labeled at two different concentrations (high-dye and low-dye).
HEK293T packaging cells were utilized to generate replication defective viruses.
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Most current gene therapy clinical trials are using viral vectors that are self-replication defective.
The control vector was a replication-defective lentivirus encoding GFP (Lenti-GFP).
Replication-defective chimpanzee adenoviruses (ChAd) are among the most promising human vaccine platforms available.
In replacement gene therapy, replication-defective viruses have been utilized as delivery vectors.
Wild type and a fiber-mutant replication-defective recombinant adenoviruses expressing β-galactosidase were used.
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