His research is about understanding how viruses remodel organelles to facilitate viral replication and spread.
Multicellular organisms evolved efficient host-defense mechanisms to sense viruses and to block their replication and spread.
Importantly, endogenous microRNA-7 expression in primary human brain resections tightly restricted replication and spread of microRNA-sensitive virus.
Neutrophils can limit viral replication and spread, as well as stimulate an effective antiviral adaptive immune response.
Scull, M. A. et al. Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways.
Moreover, we are working to understand how different bacterial and viral pathogens target the actin cytoskeleton of host cells to promote pathogen internalization, replication and spread during infection.
These genes code for proteins that attack invading viruses by mutating their DNA, a tactic that can stop or at least slow the replication and spread of the virus.
An innovative approach is virotherapy, in which viruses are engineered to infect cancer cells, resulting in tumor cell lysis and an amplification effect by viral replication and spread.
By rapidly limiting virus replication and spread this strategy may reduce the number of animals that need to be slaughtered during an outbreak.
In addition to safety, we evaluated signs of vvDD replication and spread to distant tumors, pharmacokinetics and pharmacodynamics, clinical and immune responses to vvDD.
Over years of co-evolution viruses have become experts in exploiting the host cell biology and physiology to ensure efficient replication and spread.
