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Murine cytomegalovirus (MCMV) provides a model for the analysis of replication and dissemination of HCMV [27].
While most mosquitoes did not allow active viral replication, few mosquitoes enabled replication and dissemination as efficiently as when infected with CHIKV 06.21.
These results suggest that the increased susceptibility to pulmonary infection with F. tularensis in TLR2−/− and MyD88−/− mice results from a failure to limit bacterial replication and dissemination.
Altogether, these findings suggested that the host adaptive immunity is essential to control the replication and dissemination of VACV in the murine model of tail scarification.
Investigations using RNAi in the Liverpool strain as well as in field-collected Ae. aegypti mosquito, should be the next step to assess the role of these proteins in viral replication and dissemination within the mosquito Ae. aegypti.
Prolonging the survival of infected cells is clearly in the best interest of L. pneumophila, as it will allow optimal replication and dissemination of the bacteria in the host.
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Reservoir hosts play an important role in the replication, maintenance, and dissemination of arthropodborne viruses (arboviruses).
Pathogens may also utilize the NF-κB system to enhance their own replication, survival, and dissemination within the host [ 47].
We conduct extensive simulation studies to evaluate different combinations of the replication and query dissemination algorithms.
We review several published conceptual models designed to promote the replication and widespread dissemination of effective programs, and discuss their strengths and limitations in the context of planning and implementing a complex, large-scale real-world dissemination effort.
While granulomas are composed of many different cell types, macrophages and T cells are important components that collaborate to limit bacterial replication and prevent dissemination.
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