Sentence examples for replicating vector from inspiring English sources

The vector pEPI was the first nonviral and episomally replicating vector.

The clinical stage anti-cancer agent PR-104 has potential utility as a cytotoxic prodrug for exogenous bacterial nitroreductases expressed from replicating vector platforms.

Although it has been suggested that hepatitis delta virus (HDV) can be used as a vector to deliver biologically active RNAs into hepatocytes, modified HDV as a specific transporting and replicating vector in anti-viral research has not been investigated.

The first is replicating vector pA7248AMV-GFP based on PVX genome, and the second vector pEAQ comprising fragments of CPMV genome is unable to replicate in plant cell.

Small, randomly generated genomic fragments were cloned into a conditionally replicating vector, and the resulting library of single S. typhimurium clones was grown under permissive conditions.

We also demonstrated that the designed replicating vector system has a considerable benefit in the transgene expression, if compared to the regular expression vector.

A close examination of licensed vaccines against infectious diseases reveals that some of the most potent and efficacious constructs currently in use are replicating vectors [27], [28].

The strains transformed with an integrating vector were checked by PCR with primers amplifying the corresponding promoter and reporter gene; whereas recombinant strains with replicating vectors were confirmed by recovering the plasmid after transformation into E. coli.

Thus, while vaccination with replication-restricted VACV recombinants is highly desirable for safety reasons, there might be an advantage in the use of replicating vectors eliciting prolonged immune responses.

Moreover, the immune response of replicating vector-vaccine Ad4 expressing the HA from the avian influenza H5N1 was assessed in a phase 1 clinical trial.

These data suggest the potential utility of replicating vectors expressing HIV-1 antigens.