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The lysogenic lifestyle results in the establishment of the phage genome inside the bacterial host where it can remain in a dormant state replicating together with the bacterial chromosome.
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CpG methylation patterns are replicated together with DNA replication during the S phase (Stein et al, 1982), and the altered transcriptional regulation via aberrant promoter methylation could play an important and significant role in the tumorigenic process of these ovarian cancers.
If two genes are fused, they will be replicated together and we assume them to be amplified together.
In modern cells, genes coding for different proteins can exist in the same DNA molecule (chromosome) and are replicated together.
Through cascading expression of different gene groups the virus genome finally replicates together with other virus components into cell vesicles.
In the 2nd version of the model there is a 10-3 chatceach each time step that the genes form a chromosome, and will replicate together from that point of time.
The capacity of CACs to replicate together with their ability to undergo ductal and endocrine differentiation indicate that they can behave as adult pancreatic progenitor/stem cells in vivo.
Furthermore, variants of the SCM have shown that linked genes can be selected in this model [ 25], and this is an important step to get from a situation of a protocell with a bag of independent and potentially competing genes to a modern cell with a team of linked, cooperating genes that replicate together on large chromosomes.
Each single pair mating was carried out in multiple replicates (Figure 2, Table 1), and the replicates were analyzed by both adding the results of all replicates together (sum across replicates) and by taking the average of replicates.
At each temperature and time point, triplicate biological replicates together with a blank control were prepared.
Recombination was investigated by split decomposition analysis using SplitsTree version 4.8 [ 44] with default settings (uncorrected P method) and 1000 bootstrap replicates together with Phi test for recombination [ 45].
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