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As power is a function of both the strength of the association (effect size) and the MAF of the associated variant, limitations in transethnic replicability of variants resulting from limited allelic polymorphisms in a replicating population is a notable challenge.
We consider a unicellular, asexually replicating population of organisms, whose genomes consist of a single, double-stranded DNA molecule, i.e. one chromosome.
In conclusion, the work presented here suggests that, having established themselves as a replicating population in the tsetse midgut, trypanosomes may require a NO signal and/or the presence of L-cysteine to promote migration to the salivary glands and maturation into mammalian infective forms.
Hence, slight increases in virus mutation frequencies might result in the extinction of the replicating population (Eigen, 2002; Domingo et al., 2010).
Note that, in line with the previous section, this theory is again equivalent to the general theory of fixation in a haploid, asexually replicating population [ 44, 45].
In contrast to phage-display, the peptide sequences are directly encoded in the bacterial DNA, resulting in a self-sustaining and replicating population that can easily be propagated without requiring elution from the target, thereby minimizing loss of the peptides possessing the greatest interaction.
Similar(54)
This test was applied for each AR and TW replicate population.
There was no nesting of competition assay plate within replicate population or replicate population within generation, and we thus assume that the variance among competition plates is the same for all populations and is maintained constant during experimental evolution.
The arrays were scanned in two batches of 16, balanced for replicate population of origin and replicate population of origin of the males to which they were mated [GEO GSE48385].
However, the analysis of the standardized Ln RH values for each TW replicate population showed some significant results, though they were not consistent among replicates.
When this is the purpose, having replicated populations for each direction of selection is clearly advantageous.
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