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This suggests that exposure to B[a]P may cause double strand breaks, for instance by the collapse of the replication fork in replicating cells.
(C and D ) BrdU was detected in the epidermis of His C mutant embryos indicating DNA replication but the pattern of replicating cells was distinct from wild type.
But were those replicating cells making new eggs?
Are we still the sole proprietor of our bodies?" Artificial fire opals were embedded under the silken threads of several dresses, issuing across the body in a gleaming pattern, like replicating cells.
(a) Simplified schematic of BrdU incorporation into the nascent strands of asynchronously replicating cells (adapted from Hansen, R. S. et al. Proc Natl Acad Sci U S A 107, 139 144, 2010).
18F-FLT is trapped after phosphorylation by thymidine kinase1 (TK-1), whose expression is increased in replicating cells [11].
Thus, in a population of cells composing a tissue with replicating cells, mutant cells will tend to be lost.
Therefore, camptothecin specifically introduces DSB in replicating cells, eliciting HRR.
Our investigation also revealed a significant reduction in the actively replicating cells including those belonging to the neuronal lineage in the JEV-infected SVZ niche.
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In fact, over half of Xi-replicating cells retain CIZ1 at Xi after RNase digestion (Fig. 1d).
Clearly, melphalan and cisplatin-induced ICLs can be unhooked in both replicating and non-replicating cells.
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