Drug carryover effects that lead to erroneous NR-MIC90 values for potent replicating actives are mitigated when employing the NR-CARA (Fig. 6a).
In a sense, they replicate what active managers try to do, at much lower cost.
Iversen said annihilation was a potent synthetic cannabinoid compound that replicated the active ingredients in cannabis and was among hundreds of compounds that the ACMD will recommend next week be banned by the home secretary, Theresa May.
The price to pay for the convenience of this approach is the false-positive rate that results when potent molecules active only in replicating conditions register as active candidates in nonreplicating conditions by virtue of their carryover from the nonreplicating phase to the outgrowth phase.
Acyclovir was first discovered in the mid-1970s and is effective against active, replicating HSV or VZV.
Only two transposon families in the genome are considered active, replicating themselves tidily in the course of transmission from parent to child.
Uptake is efficient and EBs differentiate to form reticulate bodies (RBs) which are the metabolically active, replicating form of the microorganism.
Further exploration of this model may reveal other players in MTB's adaptation to an active, replicating state, and it will be interesting to assess the extent to which induction of the Reaeration Response occurs in other strains, including clinical isolates.
As most common anti-tuberculosis drugs are active against actively replicating bacilli only, these dormant bacilli, or persisters, are considered the main reasons for late relapses.
Over the remaining 2 yr of the project, our goal is to build a cadre of physics instructors who are committed to replicating the interdisciplinary, active-engagement approach of the new course.
