This reflects a realistic challenge for few replicates with multiple contributors, whereby any dropin alleles may be wrongly attributed to one of the contributors.
In those NA12878 replicates with multiple FPs relative to the ASD panel callset, the majority are artifacts created by two larger structural variants in the introns of SHANK3 detected manually during the review of discordant calls.
Further work is also needed to determine if the results shown here, that multiple PfEMP1 domains can induce anti-rosetting antibodies, are replicated with other rosetting variants.
Hybridizations were replicated with dye swap.
By having suitably high ESS values, along with multiple (100) replicates with evidence for convergence across chains and visual inspection of individual chains suggesting good mixing and a lack of trends, we are confident that we generated a good sample of the posterior distribution of the parameters of interest.
Other than in dementia of the Alzheimer type in which many of the identified susceptibility genes and even of loci identified in GWA studies have been replicated by multiple studies with large sample sizes (Paulson and Igo, 2011), the genetic architecture of vascular dementia and its subtypes is less well explored.
All of the data is automatically replicated across multiple regions and with strong consistency.
Common coding variants in APOE and common noncoding variants in FOXO3A have been associated with EL and replicated across multiple populations (Deelen et al., 2011; Brooks-Wilson, 2013; Garatachea et al., 2014).
Experiments were replicated multiple times with different preparations of proteins in order to generate robust data sets that included estimates of measurement error.
First, although significant associations of variants within the CHRNA5/A3/B4 cluster with smoking have been replicated in multiple independent samples, almost all these studies were concentrated on smoking dependence in samples of European origin [14], [18], [19], [20], [21], [22], [23], [24], [25].
