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We directly replicated the top scoring SNP (rs11891311, P-value=4.78 × 10−156) reported in the Korean GWAS.
In the present study, we performed a GWAS in 1,461 subjects and replicated the top SNPs in additional 8,830 healthy Chinese Han individuals.
In order to investigate the genetic determines of serum UA in Asians, especially in Chinese, we conducted a GWA study in 3,451 individuals, and subsequently replicated the top SNPs in additional 8,830 healthy participants.
We performed a GWAS analyzing the association between 658,288 autosomal SNPs and serum ALP in 1,461 subjects, and replicated the top SNPs in an additional 8,830 healthy Chinese Han individuals.
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We replicated the top-ranked CpG classifier using an alternative, clinical DNA methylation assay (P = 0.039).
Four major companies — ExxonMobil, Shell, Chevron and ConocoPhillips — have promised to invest $1 billion in new response capacity that would broadly replicate the "top kill" technology that took BP months of floundering to find; BP says it will join the effort.
I look forward to seeing how the other presenters fit into this mould in the coming weeks, but going by the first episode Evans and co will have to try a lot harder to replicate the Top Gear that a nation has grown to love.
The Family Blood Pressure Program tried to replicate the top six SNPs identified by the WTCCC but failed to do so [10].
In the present report, we aimed at replicating the top nine novel associations with type 2 diabetes in seven loci in a Danish case-control study (excluding the previously investigated PPARG variant) followed by a meta-analysis of our data and reported association studies.
However, we failed to replicate the top SNPs in the other loci of SEC22B, CENTG2, TET2, VEGFC, and TNFRSF11B in the validations stage (Additional file 4: Table S2).
Our aim in this new study was to greatly expand the scope of our analysis using our sample of over 7,900 twins, replicating the top several thousand associations from an initial GWAS in a second sample before narrowing in to validate and extend the associations across the normal distribution of g scores in the population.
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