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More than one therapeutic drug may be associated with each replicated target; * Drug databases shown are examples.
These are formed as a direct consequence of transposition of the Ac/fAc termini into a replicated target site on the sister chromatid (Zhang et al., 2013).
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Table 2 shows the 24 replicated targets with examples of replicated drugs found in our study.
Mutations in critical genes in replicating target cells.
These homologous, yet divergent nuclear and mtDNA sequences can be co-amplified in PCR reactions intended to replicate targeted mtDNA sequences only.
And I have always worried about the microcompartments seen in vents not serving the role that I think compartments need to serve, as differentially replicating targets of natural selection.
We performed a binary classification of the 192 predicted therapeutic targets to distinguish novel and replicated therapeutic targets.
When >1 replicate target assay (HEV or PAdV) was positive, the sample was considered positive.
These key events focus on effects in critical genes, in critical replicating target cells.
When analysed per protocol, the technical replicates (target replicates: 3 for the somatic tissues; 2 for the embryonic stages; array replicates: 4 per target) proved to be nicely correlated as evidenced by the corresponding scatter plots (Fig. 4A B).
As part of this process, all replicate target sequences were removed along with sequences that were too short for probe design.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com