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A/chicken/Krasnodar/123/2006 virus had MID50 and MLD50 values similar to those of A/goose/Krasnoozerskoye/627/2005 virus but was recovered only from mouse lungs, where it replicated to lower titers (Table 2).
The other group (three replicates, lower initial mineralization activity, LA) did not receive a second SMZ dose and was transferred to the soil after 15 days of inoculation.
For each of the 8 cell types in the gene expression data matrix, we considered silent those genes showing median expression value, across replicates, lower than the threshold.
At one end of the spectrum, the individual components of a multi-strain vaccine can show "interference," in which one or more strains replicate to lower levels or stimulate a poorer immune response in a combined vaccine than a single-strain vaccine.
The isolate of ANDV we are using consistently replicates to lower titers than does the SN77734 isolate of SNV, although here we show that both viruses activate a similar IFNλ profile.
However, thus far, we have failed to replicate significantly lower Aβ42 levels or Aβ42/Aβ40 ratios in plasma from AD patients.
The findings obtained in studies performed with DNA viruses, which replicate with lower error rate than RNA viruses, are more difficult to compare to our results [ 30].
We were able to replicate the lower levels of contactin-1 in patients with postoperative delirium in the validation cohort, though the trend did not reach statistical significance (p = 0.086), which might be due to the limited power of our analysis.
Possible explanations for the differences in VEE complex viremia levels in different rat populations include the following: 1) EVEV may generally replicate at lower levels in a variety of rodents, or 2) cotton rats from southern Florida are more resistant to the replication of VEE complex alphaviruses.
