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After controlling for current levels of depression and anxiety symptoms, the G × E interactions become stronger and were replicated in the analysis using the biallelic classification.
The justification for more complex interventions to improve primary care depression treatment is replicated in the analysis of included studies and basically goes in line with a previous review [ 21], however, we did find more evidence in newer studies that support guideline implementation to be effective in symptom reduction.
Similar(58)
Results concerning gastric-bleeding prevention were consistent with the prior meta-analysis [ 12] and were replicated in the current analysis as we found no evidence that H2RA and sucralfate differ with respect to the prevention of overt bleeding.
These results were nearly replicated in the MDR analysis.
The established theoretical scales were largely replicated in the exploratory analysis.
Moreover, the significant haplotype association of SNP2-SNP7 was replicated in the cumulative analysis of our two sample sets.
Moreover, these results were reproduced in all haploblocks regardless of different SNP combinations and were nearly replicated in the MDR analysis.
Our short term interim analysis showed a significantly larger increase in folate concentration in the placebo group, 12 a finding that was initially replicated in the current analysis but that disappeared after adjustment for body mass index and smoking.
Although significant association of the disease was observed with neither genotype, allele frequencies of SNP2 (P = 0.195, P = 0.178, respectively), nor haplotypes of SNP2-SNP7 (P = 0.084) in the second sample set, the significant haplotype association of SNP2-SNP7 was replicated in the cumulative analysis including the two sample sets (P = 5.0 × 10-4) (Table 4 - additional file 4. ).
The major changes in gene expression in the CF intestine reported previously were replicated in the new analysis (both complete datasets are deposited at Genome Expression Omnibus website, GEO Series accession numbers GSE765 and GSE18327, respectively, at http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi acc=GSE765 and http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi acc=GSE18327.nih.gov/geo/query/acc.cgi acc=GSE18327
In addition, the primary results using multiple imputation for missing data were similar when replicated in the secondary analysis of 455 patients, which excluded those with complete missing data for the primary exposure, with a hazard ratio for each additional adherent ventilator setting of 0.96 (95% confidence interval 0.94 to 0.99, P=0.001).
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