Of the 182 BXD eQTL, 22 have a local eQTL in Qrr1 and 11 of these local eQTL could be replicated in MDP (Table S1).
No other results were replicated in G-EAR (Table 5).
The two SNPs both replicated in this cohort (table 3): combined analyses of all 2941 cases and 3102 controls typed for these SNPs (table 3) yielding highly significant Pcomb values (4.24×10−10 for rs35656932 and 2.44×10−9 for rs13208096).
Most previous GWAS loci for circulating lipids were replicated in our data (Table 4) but only few of the findings of GWAS of BMI and BP were replicated (Table S2).
Many of the SNPs in the HLA region and one PTPN22 SNP (rs2476601) from EIRA were well replicated in NARAC (see table 3 in online supplement).
All three tag SNPs are associated with maximum BMI measured during adulthood and childhood in Sample 1, but only rs11652094 and rs10468608 replicated in Sample 2 (Table 3).
The association of MetS with residence, age, BMI, marital status, and siesta time per day was found to be statistically significant in univariate analysis (Additional file 2) and replicated in multivariate analysis (Table 3).
Ten out of twelve virus isolates replicated in U87.CD4.CCR5 cells (Table 1), while three U87.CD4.CXCR4 cultures were productively infected, as monitored both by p24 antigen production and syncytium formation.
Many candidate-gene studies and a single genome-wide association study spanning the pre-cART and cART eras, primarily focusing on HAD with or without HIV encephalitis, have identified variants in immune-regulatory genes and other gene classes as potential risk-modifiers or protective factors, but very few of these genes have been replicated in subsequent studies (Table 1) [ 31, 32].
The association results in the Plains Indians were replicated in the U.S. Caucasians (Table 5).
However, none of these SNPs were replicated in our validation set (Table 2).
