While the proportion of cells in S phase was increased after 24 h treatment with 0.1 10 µM AZA or DAC, only longer incubation times resulted in a decrease of replicating cells for several drug concentrations (Figure S1A).
There were wide variations between the replicates for several of the parameters analysed.
Each dataset is composed of multiple technical replicates for several distinct microarray platforms (see Supplementary Table S1).
Company laws are easily replicated, for instance.
These comprised 45 probes for the homology-found miRNAs, 2 for special silkworm miRNAs, 4 for the antisense strands of miRNAs, 42 for miRNAs of other organisms, and 13 as replicate probes for several miRNAs.
These comprised 45 probes for the miRNAs identified by homology searching, 2 for silkworm-specific miRNAs, 4 for the antisense strands of miRNAs, 42 for miRNAs of other organisms non-homologous to the silkworm genome, and 13 as replicate probes for several miRNAs.
This self-generation suppression effect has since been replicated in several studies (for a comprehensive review, see Hughes et al., 2012) and it is usually believed to result from predictive processing.
Structural features of these protein ligand interactions have been replicated by several recent synthetic ligands for the p300/CBP bromodomain, which will be discussed in section 5.3.
They found they could replicate the process for several different fingers for several different volunteers taking very little time using common equipment.
