Eight studies validated their findings further in internal independent replication samples, while another two studies replicated findings of significant associations from proceeding EWASs [ 16, 22].
We demonstrate that 1) the probability of replication becomes smaller as the number of independent GWA studies increases if the power of individual replication studies is less than 100% (which is usually the case), and 2) statistically replicated findings are not necessarily true, although replication lessens the likelihood of the initial finding being false.
Figuring out the mechanism would be a major fruit of the new studies, which have produced "one of the few strongly replicated findings that has emerged from the field of heart attack and coronary heart disease," Dr. O'Donnell said.
For newly acquired memories, we replicated findings from many previous studies by showing prominent suppression-induced forgetting for the NoThink trials compared with the baseline trials3,11,18, which is in conjunction with significant reduction in SCR.
Replicated findings have been found between 25OHD concentrations and (a) two SNPs in GC (rs4588, rs7041), (b) one SNP in VDR (rs10735810), and (c) one SNP in CYP27B1 (rs10877012).
The study replicated findings from previous studies: callous-unemotional behaviour is underpinned by genes, meaning that in the instance of one twin exhibiting callous-unemotional behaviours, callous-unemotional behaviours were significantly more likely to be shared by an identical twin than a fraternal twin.
This study replicated findings related to FKBP5 and depression but not PTSD.
Burt's research gives insight into a strategy that has become one of the most reliable and replicated findings in network science over the last 30 years.
Other replicated findings have been obtained for associations between childhood trauma, suicide attempts, and substance misuse in BD, following initial findings reviewed by Daruy-Filho et al. (2011).
