If we replicate Figure 4 times, the total expected energy consumption becomes (30).
However, at 4-BPB concentrations greater than 0.5 µM invaded parasites were inhibited in replication and remained permanently in single-parasite vacuoles even when they were given 48 hrs to invade and replicate (Figure 1C) and failed to lyse out of their host cell after 2 weeks (data not shown).
Their suggested methodology can only replicate Figure 2 in my article, which shows the cumulative distribution of the mean frequencies of individual incubation periods.
DOI: http://dx.doi.org/10.7554/eLife.04811.015 10.7554/eLiFigure11.016 figure 6—figure supplement 5. Simulation results replicating Figure 6, with the difference that the initial internal state was zero, and also m = n = 1.
This figure almost exactly replicates Figure eight of the prior study [ 29], with the only exception that we also show correlation indices for pairs of units with zero distance separating them.
DOI: http://dx.doi.org/10.7554/eLife.04811.014 10.7554/eLiFigure11.015 Figure 6 figure supplement 4. Simulation results replicating Figure 6, with the difference that the initial internal state was zero, and the rate of exploration, β, was 0.03.
The parameters of the model where as follows: α = 0.4, β = 0.05, γ = 0.9, n = 4. DOI: http://dx.doi.org/10.7554/eLife.04811.013 10.7554/eLiFigure11.014 Figure 6 figure supplement 3. Simulation results replicating Figure 6, with the difference that the initial internal state was zero.
DOI: http://dx.doi.org/10.7554/eLife.04811.016 10.7554/eLiFigure11.017 Figure 6 figure supplement 6. Simulation results replicating Figure 6, with the difference that the initial internal state was zero, and the discount factor, γ, was zero.
DOI: http://dx.doi.org/10.7554/eLife.04811.017 10.7554/eLiFigure11.018 Figure 6 figure supplement 7. Simulation results replicating Figure 6, with the difference that the initial internal state was zero, and the discount factor, γ, was one (no discounting).
This experiment replicates figures 6B, 6C, and table S4 of the original article, which assess tumor growth by weight of the tumor 30 days after implantation, lymphocytic infiltration by immunohistochemistry, and toxicity by blood analysis.
