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For 24 out of 57 the replicated examples of epistasis, the interaction explains more variance than the additive effects of the SNPs.
10.7554/eLife.01381.032 Figure 3. Variance explained by additive and interacting variants for 57 replicated examples of epistasis in the GEUVADIS cohort.
For the 131 replicated examples of epistasis we identified all eQTL for the relevant genes amongst all sequenced cis SNPs or indels (a forward stepwise scan identified all eQTL significant with p<10−5, 'Materials and methods').
Firstly, we corrected a mistake while converting the GEUVADIS dataset genotype information; in combination with the new approach to detect more than one epistatic interaction, this resulted in substantially more replicated examples of both v-eQTL and epistasis in the GEUVADIS cohort.
This represents one of the first replicated examples of a differential association between these two closely related phenotypes.
The paucity of replicated examples of GWAS-derived loci that interact with lifestyle factors may be due to the low prioritization of follow-up studies by investigators and journal editors or that not all GWAS-derived loci have been examined for interactions in well-designed studies.
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The game has a cult following as a rarely replicated example of gameplay and narrative.
Because we were able to replicate more examples of epistasis, we have expanded our discussion of the relative impact of interacting and additive effects on variance, including new figures.
Table 2 shows the 24 replicated targets with examples of replicated drugs found in our study.
Today's veterans are eager to earn post-secondary degrees — and to replicate the example of the generation that returned from World War II and fueled our prosperity.
Those gains have been achieved amid a political controversy that has at times seemed almost unprecedented but which in many ways replicates the example of two of the law's forerunners, Medicare and Medicaid.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com