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There is already replicated evidence for association of SNP within this gene with JIA in US and German cohorts.
Replicated evidence also exists for pre-reading and spelling interventions [ 15, 22, 23] and alternative or augmentative communication methods [ 24- 28] that work on communication skills.
Presenting a specific case study of evolution in response to anthropogenic influences, Marnocha et al. (2011) provide replicated evidence for morphological evolution of island lizards in response to alterations of habitat structure.
Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.
Suga et al. found statistically significant associations with rs3744355 in the 5′ flanking region of the LIG3 gene and acute radiation-induced skin reactions in the Japanese population and Murray et al. provided replicated evidence for this association in a European Caucasian population [ 12, 13].
None of the variants were impressively associated with T2DM in the standard case-control analysis, but in analysis incorporating parent-of-origin effects, there was statistically compelling and independently replicated evidence for association with the maternal allele but not the paternal allele at two SNPs at 11p15 and one SNP at 7q32.
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Our results replicate evidence for increased risk of cardiovascular outcomes from wildfire PM2.5 and suggest that cardiovascular health should be considered when evaluating the public health burden of wildfire smoke.
This pattern replicates evidence from across the typical developmental spectrum (Doherty-Sneddon et al., 2000) as well as recent reports from ASD and WS that involved different individuals (Doherty-Sneddon et al., in press).
While discovering and replicating evidence of GEIs is proceeding, the process of discussing and planning how such data can be translated into the clinical arena should already be underway.
In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families.
These findings support the hypothesis that replicated scientific evidence alone does not easily change physician behaviours [ 16], unless evidence-supported clinical practices are accepted by the general public and supported by health policies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com