This case study illustrates a specific example of the benefits, and limitations, of semantically replicating data discovery.
Later experimenters could not replicate the discovery, and it was dismissed as an error for many years.
We identified 83 SNP-SNP models that replicated across the discovery and replication datasets.
The results should be seen as a curiosity rather than a discovery until replicated and investigated further, Albertini said.
A few studies utilized samples with early-onset or morbid obesity for discovery, and replicated previously reported association signals on BMI [7], [14] [16], or implicated specific genetic variants such as a recurrent 16p11.2 deletion [17].
In summary, six of the seven discovery CpGs replicated (P < 0.05), and in the same direction as seen previously.
The only other reported biparental population and multisite apple QTL mapping experiment was carried out using 251 seedlings from a 'Fiesta' × 'Discovery' population replicated in three locations in Switzerland.
Therefore, we first analyzed cohort 1 (discovery cohort) and replicated our findings in cohort 2 (replication cohort).
Identifying exact causative genes has been challenging, with many discoveries not replicated.
What really seemed to explain the silence on Monday night was the simple fact that Ms. Olsen has found her sound — her voice, alone and untreated and slow, conjoined with the specific resonance of her guitar — and she's able to replicate a private discovery in front of a crowd.
