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In all the models, the results in Tables 3 and 4 are replicated consistently.
However, rs780094 has been replicated consistently and is in high LD with a reportedly functional variant, rs1260326, in European-ancestry populations.
However, very few markers have been replicated consistently between studies.
Four loci achieved genome-wide significance for AD and replicated consistently across all cohorts.
Results of some studies have been encouraging, but these results have not been replicated consistently in subsequent, larger studies.
However, the breast and prostate cancer results have not been replicated consistently, either historically 34, 37, 41, 42 or in this study.
Similar(51)
One of the difficulties related to echo-optimization is ability to replicate consistently echoes.
Some SNPs in ADARB2 replicate consistently in the four populations and suggest a strong effect that is independent of the different genetic backgrounds and environments.
At the same time, biological candidates such as those identified through hypothesis driven candidate gene approaches may not yield p-values significant after correction for multiple testing in GWAS but may replicate consistently over many populations tested.
That is, they have been notoriously difficult to replicate consistently.
GWAS on lung function have considered genetic effects alone; a recent review [ 18] showed that most GWAS findings do not replicate consistently, which may imply a role played by environmental exposures and gene-environmental interactions.
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