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Gut inflammatory diseases such as IBD have been long known as having a substantial genetic predisposition component and a recent review of genome-wide scans reported on the seven confirmed and replicated cases of genetic susceptibility loci, with many more, however, that need independent confirmation and verification [42].
In minimally replicated cases (n = 2), it appears that the reference design outperforms the classical loop design whereby a sample from each animal is used for only one particular array hybridization.
The detailed results for all replicated cases are shown in Fig. 4 (bottom).
This cost treatment does not explicitly change the sample distribution and avoids the possible overtraining that it is present in the ROS solutions due to replicated cases.
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Cases are treated as experiments in which the hypotheses are replicated case by case.
This is achieved by eliminating cases of the majority class (undersampling) or replicating cases of the minority class (oversampling).
It is also helpful to make accessible a table of the medical OXMIS and Read codes used for diagnosis (or the mapping of these codes to specific ICD codes), so that others studying the disease can replicate case identification criteria.
Following the process of replication logic, data were first collected in Case 1 and then replicated in Case 2 in exactly the same way.
Association of rs1344706 in the ZNF804A gene (2q32.1) with schizophrenia was first reported in a genome wide scan conducted in a sample of 479 cases and replicated in 6666 cases.
Therefore, in order to draw practical implication, we can say that this study can be replicated in case of other regional blocks.
In the second series of experiments, we replicated a case of epilepsy, one of the most common neurological diseases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com