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Cases are treated as experiments in which the hypotheses are replicated case by case.
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Gut inflammatory diseases such as IBD have been long known as having a substantial genetic predisposition component and a recent review of genome-wide scans reported on the seven confirmed and replicated cases of genetic susceptibility loci, with many more, however, that need independent confirmation and verification [42].
It is also helpful to make accessible a table of the medical OXMIS and Read codes used for diagnosis (or the mapping of these codes to specific ICD codes), so that others studying the disease can replicate case identification criteria.
This is achieved by eliminating cases of the majority class (undersampling) or replicating cases of the minority class (oversampling).
Following the process of replication logic, data were first collected in Case 1 and then replicated in Case 2 in exactly the same way.
Therefore, in order to draw practical implication, we can say that this study can be replicated in case of other regional blocks.
In the second series of experiments, we replicated a case of epilepsy, one of the most common neurological diseases.
Trope et al. (2001) further replicated this case report with 16 subjects having a history of elevated blood lead levels before 5 years of age (23 65 μg/dL).
Frequencies for each SNP were averaged over four replicate case and three replicate control arrays for the Illumina HumanHap300 and eight each for the Sentrix HumanHap240S arrays.
Analysis of replicate case series, including the 128 BCP ALL cases new to this study, suggest strongly that the association with DP2 was unlikely to be due to chance.
In order to validate our findings, we replicated our case-control association tests in two larger cohorts (Table 3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com