Increased density and altered spatial distribution of subcortical white matter neurons (WMNs) represents one of the more well replicated cellular alterations found in schizophrenia and related disease.
We reasoned that these Sca6 KI models should replicate transcriptional alterations associated with SCA6 pathogenesis.
Experiments were completed with modern maize to replicate the alteration observed in the prehistoric starch.
The additional datasets are replicated experiments measuring alteration of the transcriptome through response variation within a single genotype [Development; [33]) and by abiotic stress (Abiotic; [34]].
The pyrosequencing analysis confirmed the tiling array and mass spectrometry bisulfite procedures, and replicated the observed alteration in DNA methylation performed in the individual animals compared to the pooled samples for KCNE2 and RGD1561412/Olf735 promoters (Fig. 5).
Grade II astrocytomas have been less well studied, with gains in 7q described in two studies [ 7, 12], and other alterations not replicated [ 7, 12, 46].
Ordinarily, a single UCMS regimen is sufficient to induce behavioural alterations, which was replicated here on the coat state.
Minus : no inhibition observed using the highest test concentration of 1000 μg mL−1; asterisks : the inhibitory effect was confirmed by 3 replicates; x: alterations in growth morphology (branching); n.t.: not tested.
Such alteration in basal sensitivity was replicated in humans, illustrated by a decreased sensitivity to electrical stimulus [20].
When such a spontaneous response is assessed the behavioural response seen in the Mc1re mice is replicated in the Ay-Jkn1 mice, with no alteration observed in the control non-Ay-Jkn1 littermates.
