To do so we have departed from standard practice by identifying regulatory regions which replicate across samples and connect them to the genes they control through robust re-analysis of public data.
The first series of studies identifying genetic markers for MRI phenotypes that replicated across independent samples, used a Norwegian discovery sample and replicated the findings in the ADNI or PING cohorts (Joyner et al. 2009; Rimol et al. 2010; Bakken et al. 2012).
Clearly, even where significant associations are replicated across several samples, the variants that have been found have only a small contributory effect to the etiology of dyslexia.
EFA provides a technique by which to delineate whether, at the item level, the factor structure, proportion of variation, and factor correlations can be replicated across various sample populations.
Since the identified factor structure could be replicated across all three samples it can be considered to be stable despite of the application of modifications [ 54].
Most changes in GO terms replicate across these samples, this strongly indicates that these reflect real responses to a reduction in SMN.
Developmental dyslexia is often presented as a success story for the field of genetics because specific linkages on chromosomes 6 and 15 have now been replicated across a number of samples.
On each plate, every sample was replicated across four neighbouring wells, resulting in a maximum of 96 samples per plate.
The fact that the genes we discovered were members of TG modules in all three independent sets of samples and replicated across two populations provides strong evidence that the TG genes identified are genuine signals of biological importance.
To confirm that fragments were being consistently amplified, one sample was replicated across all runs.
None of the 16 SNPs were consistently replicated across the Belgian and Canadian CD sample sets, or in the combined analysis of the Belgian-Canadian CD samples (Table 3), supporting the exclusion of the MEFV region as a risk factor contributing to CD susceptibility.
