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Precisely replicate the outcome in a virtual environment and set the number of simulations to a statistically significant level.
The simulation framework was used to replicate the outcome of virtual studies with the same design as study NO16853 using different capecitabine starting doses (825 mg/m, 1,000 mg/m, and 1,249 mg/m twice daily, days 1 14) in combination with docetaxel (75 mg/m, day 1) every 3 weeks compared with a reference arm receiving capecitabine 1,250 mg/m with docetaxel.
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The project's algorithmic approach is designed to replicate the outcomes generated by the traditional one-on-one consultative process, but with enormous transaction costs savings.
Over the last decade, thousands of people have visited East Lake to learn and see if they could replicate the outcomes in their own community.
We sought to replicate the outcomes previously reported among state quitline participants and to extend them by examining additional indicators of oral disease, behavioral risk behaviors, and motivation for change.
This behavior replicated the outcome of a previous diversity study based on SSR markers [ 17], thereby further supporting the hypothesis that eggplant was domesticated independently in the Indian subcontinent and in China [ 47, 49].
This replicates the outcomes of an earlier preliminary study using the Worry program [27] and extends those results by confirming the stability or improvement of clinical gains 3 months post-program.
However, the Hoosier Oncology Group HOGG) [ 6], who published the only full article on a randomized phase III trial thus far, failed to replicate the encouraging outcome of SWOG 9504 by randomly delivering either docetaxel or observation after CRT.
Using a computer simulation model based on the outcomes of EMPHASIS-HF to replicate the trial outcomes, extrapolate these over a patient's lifetime and capture resource and health-related quality-of-life (utility) consequences produced incremental cost-effectiveness ratios (ICERs) of £3520 per quality-adjusted life year (QALY) for the UK and €5532 for Spain.
The relevance of the findings from studies conducted in cell systems and rodent models to human physiology is not clear because the NNS data obtained from studies conducted in people often fail to replicate the metabolic outcomes observed in vitro and in animal models (rev. in 13).
Experiment 2 was designed to replicate the significant cognitive outcome effects, and also to test the hypothesis that psychological damage is a likely consequence of skinfold caliper use-and that hypothesis was refuted.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com