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Adequately powered replication studies are critical in order to replicate the initial GWAS findings.
But none of those critics had actually tried to replicate the initial results.
These factors may have impacted on our ability to replicate the initial association with steatohepatitis in a multivariate analysis.
They only shared their spreadsheet with the Herndon, Ash and Pollin after the latter three tried to replicate the initial results and failed.
However, some scientists have failed to replicate the initial findings, which suggested that PYY3-36 cut cut weight by 20% in rats.
The current study was designed to replicate the initial pilot study findings in a larger sample that was powered to detect the expected symptom-improvement difference between EFMT and the sham-training group.
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We therefore urge the authors of the original paper to clarify the uncertainty surrounding NgAgo and provide all the necessary details for replicating the initial, very important results.
We show in Table 1 the PPV values corresponding to various situations where follow-up studies replicated the initial finding.
In the second phase, we successfully replicated the initial positive results with another cohort (Group 2) of 299 cases and 299 controls recruited using the same criteria.
None of these results replicated the initial significant findings observed in the Belgian exploratory UC sample set (Table 4, Figure 2B, Table S1).
Meta-analysis also replicated the initial association between rs11646213 and SBP (P < 0.008) (Table 2).
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CEO of Professional Science Editing for Scientists @ prosciediting.com