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Thirty-year-old Abdi Abdirahman, a two-time Olympian in the 10,000 meters, went so far as to study all of the hills so he could replicate the course on his training routes in Flagstaff, Ariz.
A condition of award was that states agree to replicate the course at least once in the subsequent year, to be taught by in-state trainers who had completed the training course.
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"I had no intention of replicating the course," he said.
Developers have spent years replicating the course in exact detail.
First, there is no small animal model of spontaneous sarcoma formation that accurately replicates the course of the human disease 40.
To date, six states have replicated the course two or more times; three have offered it once, and two are in the planning stages for their first or second replication.
In this model, the hypothetical cohort of patients moves between discrete health states to replicate the natural course of the condition, with each state having associated costs and quality of life.
While much effort has been invested in the development of mechanistic models that replicate the time course of ECG changes, it is unclear how and at what point these will be used in the drug development process.
The rapid onset of the motor stereotypies and need to sequentially use dopamine antagonist and agonist drugs certainly do not replicate the delayed course and spontaneous occurrence of TD in humans treated with dopamine receptor-blocking agents.
Rockland Community College spent the last four years teaching a dozen of its counterparts how to replicate the philosophy courses at Yale and the "history of ideas" as envisioned by Columbia.
A single nigral injection of LPS resulted in acute, dramatic nigral neuroinflammation and DA neuron loss in mutant α-syn Tg mice (Gao et al. 2008), but that acute two-hit model did not replicate the chronic, progressive course of PD, and acute, robust, and localized nigral inflammation may not be highly relevant to potential etiologies or pathogenesis of PD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com