Exact(1)
We chose a "best subset" of these models on the basis of optimal error distributions for individual replicate models (34 ): median area predicted across all replicate modes was calculated, and the 20 models with predicted areas closest to the median were chosen for further consideration.
Similar(59)
However, a series of recent studies has demonstrated that mammalian mtDNA replicates via two replication modes, neither of which is identical to the strand-displacement model [3 7].
Even satellite chromosome-specific sequences (pericentromeric non-coding DNA arrays), which normally display synchrony in replication of homologous counterparts, similar to biallelically expressed genes, change their inherent replication mode and replicate asynchronously in lymphocytes of patients with cancer, including ovarian [ 34], hematological [ 35] and prostate cancers [ 26].
Furthermore, chromosome-specific sequences (pericentromeric, unexpressed DNA arrays), which normally display synchrony in replication of homologous counterparts, similar to biallelically expressed genes, change their inherent replication mode and replicate asynchronously in lymphocytes of patients with cancer, including ovarian [ 18], hematological [ 16] and prostate [ 8, 17] malignancies.
Notably, unlike in adult human hearts, in 2D-AGE of PvuII digested heart mtDNA of newborns, a faint bubble arc can be seen (Figure 2B: bu) indicating that at least some molecules are replicating via the theta-replication mode typical for cultured cells and most mammalian tissues [5].
According to our results, each of the cancer patients had an allele-specific replication mode for loci that normally replicate in the classical biallelic-mode.
Although a minority of cpDNA has a single copy of rDNA, replication intermediates are similarly complex to major cpDNA with inverted rDNA (Shaver et al. 2008), suggesting that the former may replicate in another mode, such as rolling circle replication (RCR) as discussed next.
However, focusing solely on what makes the Philippines different runs the risk of replicating the very modes of exclusion it tries to veer away from.
The high speed cyclic bend test was found to be able to replicate the failure mode and the performance ranking of the solder joints in the board level drop-shock test, while the ball impact shear test was found to have poor correlation with the board level drop-shock test.
The 10 replicates for each choice of K were summarized using CLUMPP (Jakobsson and Rosenberg 2007) with the Large K Greedy algorithm (10,000 random permutations) to identify common modes among replicates and to combine the clustering results across replicates.
The model, designed to work in forecast mode, can replicate the main oceanographic features in the region.
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