In recent years, GAG-replenishment therapy has widened the therapeutic options for patients with HC [ 130].
These findings provide strong rationale for the study of ACE inhibitors and vitamin D replenishment as preventive therapies in this high-risk population.
In severe arterial hypotension, however, the treatment response to these interventions may be too slow to rapidly increase arterial blood pressure levels to currently recommended levels (for example, a mean arterial blood pressure ≥65 mmHg [ 3, 4]), despite reversal of the underlying pathology (for example, replenishment of hypovolemia, inotropic therapy).
Therefore, besides EPO, therapy includes iron replenishment.
The CD4+ T cell reservoir latent harboring HIV-1 is established very early in infection [37], [38] and it persists throughout the course of infection [39], [40] with apparent replenishment even in individuals undergoing successful HAART therapy [39], [40].
The identification of growth factors and growth factor receptors in taste buds raises the possibility of developing therapies to increase the survival and replenishment of taste bud cells.
The treatment management of cholera revolves around the oral or Intravenous (I/V) replenishment of the lost fluid, which is the mainstay therapy for these patients [10], [11].
Replenishment of the brain Cr pool is the only effective therapy for Cr deficiency diseases (Battini et al., 2002; Schulze et al., 2001; Stockler et al., 1996).
Nevertheless, lung disease due to AAT deficiency can be prevented by protein augmentation therapy (American Thoracic/European Respiratory Society, 2003; Wewers et al, 1987) or replenishment of the deficient gene product via AAV-mediated muscle-directed gene therapy (Brantly et al, 2009; Flotte et al, 2004).
Therefore, therapy includes not only recombinant EPO, but also iron replenishment [ 8– 10].
