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2) Other forms of analysis of the p-values of the replay sequences.
In contrast, nonRR VTA neurons did not coordinate with the specific spatial content of replay sequences.
Firstly, to illustrate my analysis of the p-values of the replay sequences in another way, I have shown the source of the p-values (posterior probability) of the replay sequences in Figure 5 and Figure 5 figure supplement 1.
The encoded map thus appears to serve as a template for generating replay sequences and facilitating imaginative navigation.
Reviewer #1: This paper reports that one can predict which actions a rat will take, from replay sequences and firing rates at a decision point.
Summary: This paper reports that one can predict which actions a rat will take, from replay sequences and firing rates at a decision point.
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The coordination of a reward prediction error signal with a hippocampal replay sequence (for example, one that represents a trajectory towards a reward) could function to reinforce specific elements of the reactivated sequence, such as a goal location.
One possible explanation for this distinction, consistent with the suggested role of dopamine as a teaching signal, is that VTA dopamine activity stabilizes and links replayed sequences in quiet wakefulness across brain regions for subsequent consolidative processes in SWS.
Replay of sequences leading towards goal locations has previously been linked with the planning of future trajectories (Pfeiffer and Foster, 2013).
Corn kept clicking the mouse, playing and replaying alternative sequences that ran only a few seconds each.
However, it is an unresolved issue whether the temporally coordinated replay of sequence firing patterns in the hippocampus is indeed critical to episodic memory consolidation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com