Exact(1)
We hope that this work will be a step forward towards routine implementation of mathematical models for personalising oncology schedules, and for replacing trial and error methods in drug development by more rational methods leading to efficacious administration of drugs with increased patients' compliance.
Similar(59)
This could be alleviated by (i) replacing trial-and-error approaches with molecular/physiological target-based simple bioassays to screen test compounds at the early stages of development, and (ii) limiting large-scale synthesis for conventional evaluations of only biochemically/physiologically active compounds.
A further literature search was performed as above replacing trials with nurse.
Thank goodness computers still can't replace trial lawyers (though I bet John Edwards wishes they could).
The original efficacy or effectiveness trial was sought to replace trials that reported cost effectiveness outcomes, and no publication date restrictions were applied.
Trials were ordered using the same ABBA design as in Experiment 1, with VH trials replacing VV trials and HV trials replacing HH trials.
Should the uterus remain atonic despite the trial intervention, the obstetrician/anaesthetist can use an additional uterotonic agent either replacing the trial infusion with a known infusion of oxytocin and/or use of a further agent.
If the uterus remained atonic despite the trial intervention, the obstetrician or anaesthetist could use an additional uterotonic agent by replacing the trial infusion with a known oxytocin infusion or by using other additional agents (or both).
The exception is trial 44, where φ is not defined because the directional error (138°) cannot be reduced to the plausible range by replacing the trial's target with either of the other two targets (see Methods).
The influence of missing data was examined by replacing missing trial HbA1c values with routine clinic values where possible.
If the objective value of trial vector y p.q t+1 is bigger than objective value of trial vector x p,q t, trial vector y p.q t+1 will replace the trial vector x p,q t.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com