Replacing positions 113,705,260 - 113,705,609 with our sequence [GenBank:JN589014.1] results in a protein sequence which is very similar to the human ortholog [GenBank:NP_000675.1] (96.6% identical, one gap).
To test this prediction further, we replaced position 69 with tyrosine, which has only an average frequency (0.88) at helix-capping sites, compared to 1.41 for threonine, which is the second most abundant residue at N-terminal helix caps.
All replaced positions were located at (1171) or around (1166, 1181, 1189, 1280) the viral immunodominant site near the 5-fold axis, and thus strains bearing these replacements might be considered antigenic variants.
To assess the significance of the observed overlap between correlated mutation residues and predicted interaction motifs, random 'correlated mutation' pairs were generated by replacing each position in an observed correlated mutation position pair with a randomly generated sequence position.
In addition to replacing the position made vacant by Muhr, the appointment of Kilgarriff could point to two other things.
In August, Dynegy overhauled its management structure by replacing the position of CFO with three executives, including Hugh Tarpley Hugh Tarpley, who headed the newly created corporate development department.
Dynegy, an energy trader under investigation for questionable power deals, on Tuesday said it overhauled its management structure by replacing the position of chief financial officer with three executives.
In September 2009, it was reported that Sugababes member Amelle Berrabah had left the group and Ewen would be replacing her position in the band.
Replacing occupational position with education in the analysis did not change the results.
Diversity of the heavy chain was created by randomizing four to six position, replacing the pre-existing position 95 98 of the CDR3.
