We derive the first- and second-order inclusion probabilities for both with and without replacement variations of the design.
Following Bolzano, we will here use this generalized operation of simultaneous replacement (or variation).
These inhibitors were designed to explore replacement and variation of the P1 amidine described previously [J. Med. Chem.2003, 46, 4050].
Muscle biopsies show nonspecific myopathic changes with fibrosis, fatty replacement, and variations in fiber size.
Moreover, across English districts, a study has reported replacement rate variations from 1.22 to 14.4% for hips and from 1.05 to 6.19% for knees.
For both species, the location of the field on which they bred relative to fields where annual productivity was greater than replacement best explained variation in natal dispersal distance.
Sliding-window analysis has widely been used to uncover synonymous (silent, dS) and nonsynonymous (replacement, dN) rate variation along the protein sequence and to detect regions of a protein under selective constraint (indicated by dN<dS) or positive selection (indicated by dN>dS).
Birkmeyer et al. found that for Medicare patients in 1995, lower extremity revascularization, carotid endarterectomy, back surgery, and radical prostatectomy rates had particularly high variations, and coronary artery bypass grafting (CABG), transurethral prostatectomy, mastectomy, and total hip replacement also had high variation in rates across regions [ 5].
