Sentence examples for replacement of the active from inspiring English sources

The circular dichroism spectra of the D32A variant varied by only 3.6% at 220 nm confirming that an alanine replacement of the active site Asp does not affect the conformation significantly and therefore the mutation results only in the loss of an essential functional group acting as a base in the phosphate-transfer reaction.

We have undertaken initial studies to explore the replacement of the active site metal in ECAO.

A hallmark of this subfamily is the replacement of the catalytically active cysteine residue by a corresponding serine residue (Fig. 1B).

The replacement of an active peptide at the amino terminal end (rMIII) of the platelet receptor for type III collagen with the type I collagen active peptide was done without altering the hydrophilicity of the protein.

An as yet unanswered question is the significance of this catalytic residue substitution; replacement with Ser of the active-site Cys in papain or cathepsin L abolishes enzyme activity (Clark and Lowe, 1978; Coulombe et al., 1996), so on this basis it might be predicted that the serine-type SERA proteins are proteolytically inactive.

However, about 15% of the guarding bouts are started by the replacement of an active sentinel see below.

The number of replacements/h as well as the percentage of guarding bouts starting with the replacement of an active sentinel by an M1was higher than those by an M2.

It was concluded that the replacement of an active material with an inert additive can improve cement paste performances by increasing the surface area and the packing density of the cement-based particles, mainly when limestone powders with a combination of several different particle size distributions were used due to increased packing density.

There was a drop in the number of attacks against Americans evident in recent months, and that seemed to justify reducing American troops, as well as the replacement of many of the active-duty troops with reservists.

In addition, the transfection of chemically modified CFTR mRNA in mutated CFBE41o− cells restored cAMP-induced CFTR currents similar to wild type cells due to the mRNA-driven replacement of functionally active channels [20].

The abundance of the 5 kDa form was not influenced by protease inhibitors, replacement of selenocysteine in the active site or mutation of amino acids in the cleavage site.