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The replacement of systematic fragmentation of exocyclic single bonds with a set of 13 retrosynthetic rules for MMP generation reduced the number of MMPs that were obtained by more than half.
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Indeed, DMG can be viewed as the result of systematic replacement of entities by markers and of truth values by state transitions.
Systematic replacement of the pendant aryloxy group led to identification of potent GPR40 agonists.
Design of bioactive organosilanes has often involved a systematic replacement of a bioactive molecule's stable carbon atoms with silicon.
Systematic replacement of the hydrophobic residues with adamantane amino acids resulted in a small set of compounds with varying amphipathic character.
A set of Gα12 mutations with systematic replacement of six amino acids with NAAIRS was tested for binding to the PC1 C-terminus in GST pulldowns.
A systematic replacement of the heterocyclic moiety gave access to further inhibitor classes with interesting selectivity profiles, demonstrating that the benzylidene heterocycles provide a versatile tool box for developing inhibitors of the CMGC kinase family members Dyr1A/1B, Clk1/4 and CK2.
Using this approach, we find that, whereas systematic replacement of yeast genes with the kanMX marker does not perturb the chromatin landscape, chromatin differences associated with gene position account for 35% of kanMX activity.
Schematic illustration of (a) lipid deposition on docked droplet of cytoplasmic fluid stabilising the droplet, b exchange of lipid solution to oil lipid 2, c d as oil lipid 2 is exchanged with extracellular aqueous solution the first lipid bilayer is formed, e h second lipid bi-layer formed through systematic replacement of surrounding fluid.
The dramatic result in the stability profile of a protein, due to systematic replacement of amino acids (with comparable ones) in the hydrophobic core composition is a well-known fact [59], [60].
Systematic replacement of traditional methods with other methods.
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